Objective To observe TCM syndrome types change rule of preoperative and postoperative Colorectal cancer. Methods Prospective clinical study design. We observated 146 cases of colorectal cancer confirmed by pathological examination， which would be on operation. Each one would be recognised on TCM syndrome types during the preoperative and postoperative week of Colorectal cancer， without TCM intervention therapy. Collect patients’ general information， four diagnostic data and postoperative pathologic examination results and pathological staging as observation index. Results The most TCM syndrome type of the postoperative colorectal cancer is pixu. As development of the illness， loss of healthy atmosphere， TCM syndrome type gradually turn to intermingled deficiency and excess. Middle-late colorectal cancer patients mainly have deficiency syndrome， the earlier disease the fewer deficiency syndrome is. Conclusion The colorectal cancer surgery， while removing part of pathogenic， may damage the healthy atmosphere of patients， lead to the further evolution of the disease. So the author thinks that in preoperative and postoperative colorectal cancer should be took great importance to the health of vital qi of spleen and stomach， assistance， give surport to the role of the multidisciplinary treatment.