Objective To explore the comprehensive community intervention on the impact of depression and anxiety in patients with breast cancer. Methods 112 cases of breast cancer patients were randomly divided into treatment group（n=56 and control group（n=56）. Treatment group given to the same time with “biological-psychological-social” factors in the three intervention integrated intervention， while others are the control group. All patients with breast cancer were investigated with SAS and SDS before treatment， after 6 months， 12 months. Results After 1 year ， depression and anxiety in patients with significantly improved. The differences before and after intervention was statistically significant（t=4.055， 5.540；P<0.01）， and the differences between Treatment group and the control group was statistically significant （t=-4.093， -4.836， P<0.01）. Conclusion Comprehensive community intervention can significantly improve depression and anxiety in patients with breast cancer. The degree of improvement is proportional to time and the treatment time of 12 months for the best.