Objective To study the difference between the DM patients and the early-stage DN patients and the difference between the Phlegm-damp syndrome and non-Phlegm-damp syndrome patients， 4 factors including blood glucose、blood pressure、blood lipid、blood plasma TGF-β、ET were measured. Methods 95 early-stage DN patients were involved：49 patients were involved in the Phlegm-damp syndrome group， while the other 46 patients were involved in the non-Phlegm-damp syndrome group. Another 50 diabetes patients without vascular disease were chosen as normal group. We compared the blood pressure、FPG、TG、TC and TGF-β、ET of the above groups. Results Compared with DN non-Phlegm-damp syndrome group， hypertension、lipid metabolism disorder were more common in the Phlegm-damp syndrome group；the ET level in the DN Phlegm-damp syndrome group was obviously higher than that in the non-Phlegm-damp syndrome group， and the difference was statistically significant（P<0.01）. Conclusion Hypertension、lipid metabolism disorder may connect with the TCM Phlegm-damp differentiation；The ET level might be a sensitive and ideal factor to differentiate the Phlegm-damp syndrome.