Objective Investigate the TCM Four Diagnostic Information of AIDS patients in Yunnan Province and analyze the symptom characteristics. Methods The Four Diagnostic Information questionnaire is used for collecting the information about the research objects. Results The common symptoms are successively as follows： waist and knee pain， depressed mood， dysphoria， weakness， dry throat and mouth， forgetfulness， headache， neurolysis， enuresis nocturna， insomnia， expectoration， dizziness， cardiopalmus， cough and tastelessness； tongue picture： mainly featured by pale red tongue， red tongue and thin white tongue fur， while teeth-printed tongue and thick tongue fur being often seen； the common pulse conditions are respectively as follows： thready pulse， taut pulse， rapid pulse， deep pulse and slippery pulse； and the factors of etiology and pathogenesis include： the most common qi deficiency， yin deficiency and qi depression； and the disease locations are as follows： kidney， spleen and liver mainly involved. Conclusion The AIDS patients in Yunnan Province generally have multiple clinical symptoms and signs and the composite syndrome as well as the characteristics of mixed excessiveness and deficiency and obvious deficiency， and their kidneys， spleens and livers are mainly involved； and the psychological symptoms are very common， which might also related to the dependence on heroin.