Objective The main purpose is to research the curative effect of the liver-invigorating and fat-reducing particles to the insulin resistance of nonalcoholic fatty liver disease. Methods Take patients into two groups， to observe curative effect between two groups， to analyze the reducing of insulin resistance， ALT， AST， GGT， TG， TC， LDL-C， WC， BW， BMI. Results 1. The difference between two groups′ reducing extent of IRI is significant（P<0.01）， treatment group is much better than control group. 2. The difference between two groups′ reducing extent of ALT， AST and GGT（P>0.05）are not statistically significant. 3. The difference between two groups′ reducing extent of TG， TC are significant（P<0.01）， and the difference between two groups′ reducing extent of LDL-C is not statistically significant（P>0.05）， treatment group is much better than control group. 4. The difference between two groups′ reducing extent of WC is statistically significant（P<0.05）， the difference between two groups′ reducing extent of BW is not statistically significant（P>0.05）， the difference between two groups′ reducing extent of BMI is significant （P<0.01）， treatment group is better than control group. Conclusion Liver-invigorating and fat-reducing particles can relieve the nonalcoholic fatty liver disease， and relieve the insulin resistant. It can also reduce the level of ALT， AST， GGT， TG， TC， WC， BMI.