Objective To observe the influence of Huatan Quyu Tongluo method for Acute exacerbation period of Chronic obstructive pulmonary disease（AECOPD）of Lung function And inflammatory mediators（IL-8、TNF-α、CRP）. Methods 80 patients were randomly divided into 2 groups， The treatment group to give huatan Huatan Quyu Tongluo method And conventional western medicine therapy. Conventional western medicine treatment control group. Compare two methods of curative effect， The determination of serum IL-8， TNF-α， CRP levels And testing lung function. Results The treatment group compared with control group， Serum IL-8， TNF-α， CRP and lung function（P＜0.05）have statistical significance. Conclusion Having obvious intervention effect of Huatan Quyu Tongluo method for Acute exacerbation period of Chronic obstructive pulmonary disease（AECOPD） of Lung function And inflammatory mediators（IL-8、TNF-α、CRP）. Can effectively reduce the level of IL-8、TNF-α、CRP， To improve the level of FEV1， FEV1/FVC %， Effectively improve lung function.