Clinical efficacy of traditional Chinese medicine is the foundation of existence and development. Efficacy assessment has also been core of Chinese medicine clinical problem. However， currently aspect of constructing Chinese medicine “real world” clinical evaluation has been lacking relevant theories and methods， this also is currently one large block of TCM modernization and internationalization. This paper has discussed the significance of develop comprehensive evaluation in the field of Chinese medicine clinical， has stated of the definite operation process， key link， and the problem and countermeasure of comprehensive evaluation applied in TCM field， so that it can provide certain reference to lead TCM clinical evaluation to “real world”.