Objective Discuss joint compound ɑ- keto acid made from cordyceps sinensis and optimization of protein diet on maintenance hemodialysis patients with spleen and kidney deficiency syndrome of nutritional status. Methods Observation of 60 patients with hemodialysis nutrition indicators before and after treatment（Body mass index、 Grip strength、 albumin、 hemoglobin、 prealbumin、 triglycerides、 cholesterol、 C-reactive protein）、 Blood biochemical indicators （Serum Creatinin、 blood calcium and blood phosphorus、 potassium）. Results The two groups before and after treatment propagated， albumin、 hemoglobin、 prealbumin、 triglycerides、 cholesterol、 C-reactive protein、 blood calcium and blood phosphorus was improved， the treatment group propagated， prealbumin is superior to the control group. Conclusion Joint compound ɑ-keto acid made from cordyceps sinensis and low protein diet can improve the nutritional status in patients with maintenance hemodialysis， blood lipid metabolism， calcium and phosphorus metabolism state of inflammation.