Objective To observe the effect of Wenhua Fang on chronic HBV carriers HBV-DNA copies， Fibroscan elasticity and IL10， IL17 expression level. and to explore the hepatoprotective mechanism of Wenhua fang. Methods This paper chose a randomized， single-blind， blank control way of study. 30 chronic HBV carriers were randomly divided into treatment group and control group， Treatment group use Wenhua Fang and control group use placebo for 12 weeks. Observing all cases’ HBV-DNA copies， Fibroscan elasticity and IL10， IL17 expression level. Results The HBV-DNA copies， Fibroscan elasticity and serum IL10， IL17 expression levels are significantly increased in treatment group，（P<0. 05）； and manifest no statistical significance（P>0. 05） in control group. Conclusion Wenhua fang shows significant antiviral effect on chronic HBV carriers with asdthenic splenonephro-yang. It can also alleviate liver fibrosis of chronic HBV carriers evidently. These effects may be associated with an even improving of serum IL10， IL17 expression levels in chronic HBV carries.