Objective To investigate the expression of Fas antigen in hepatocyte and determination the serum tumor necrosis factor alpha（TNF-α） of Modified Sini Decoction on Hepatocyte Apoptosis induced by Concanavalin A（Con A）. Methods The mouse were randomly divided into five groups：normal control group， model group， positive drug group， flavored SND large and small dose group， ALL groups， except for the NS group， were given Con A aqueous solution（18mg. kg-1） via tail vein injection， determination the levers of the serum tumor necrosis factor alpha（TNF-α）， and the livers were taken for for the histopathology examination， meanwhile detection of Fas antigen expressions in liver tissue sections. Results The model mice liver cells express large amounts of antigen Fas， and serum TNF-α levels also increased significantly with statistical significance（P<0. 05） difference compared with the control group；TNF drug group and the control group in serum -α levels changed little， Fas antigen expression in liver cells is not obvious. Conclusion Modified Sini decoction has protecting effect on immune Hepatocyte Apoptosis induced by Con A in mice， and the mechanism is probably to anti-Fas antigen and TNF-α.