Objective To observe the local inflammation and histopathological changing effects of YinZhi anorectal smoked lotion act on similar hemorrhoid model of rats. Methods To make similar hemorrhoid animal model use peripheral injection of acetic acid method. After the animal models are made successfully， the rats were randomly divided to YinZhi anorectal smoked lotion high， medium， low dose group， Ma Ying-Long Jin Xuan hemorrhoid washing powder control group and blank group. Rats were in continuous administration of seven days. After administration of 2， 4， 7 days observed the rats by general check on local swelling， inflammatory exudate and the ulcer area， estimated the effect of the anti-inflammatory drugs， and promoting ulcer healing， On the 8th day the animals were killed after observing. By histopathological examination， do observation of drugs on animal models of pathological changes to improve the situation. Results YinZhi anorectal smoked lotion high， medium and low dose groups after administration， have better effect than Ma Ying-Long Jin Xuan hemorrhoid washing powder control group and blank group on the improving the local symptoms（P<0.01/0.05）. YinZhi anorectal smoked lotion high， medium and low dose groups after administration， have better effect than Ma Ying-Long Jin Xuan hemorrhoid washing powder control group and blank group on improving histopathological changing of similar hemorrhoid model of animals（P<0.01/0.05）. Conclusion YinZhi anorectal smoked lotion can significantly improve the similar animal model of local symptoms；It has anti-inflammatory and promote ulcer healing；It has a fuction of improving pathological changes of the animal models.