Objective To study the chemical constituents of Sargentodoxa cuneata. Methods Sargentodoxa cuneata was extracted with 95% ethanol， and the extract was extracted with petroleum ether， ethyl acetate， n-butanol alcohol respectively. The compounds of n-butyl alcohol extract were isolated by variouscolumns and instruments， and were identified through the use of physical and chemical properties， NMR data and spectroscopy data. Results Twelve compounds were isolated， and identified as salidroside（1）， 3， 4-dihydroxy-phenethyl-β-D-glucopy ranoside（2）， 7-（4-hydroxy-3-methoxyphenyl）-N-[7′-（4′-hydroxyphenyl）ethyl]-（E）-8-propenamide（3）、eugenyl β-rutinoside（4）， Chlorogenic acid（5）， oleanolic acid（6）， （-）-epicatechin（7）， 2-Phenylethyl-β-D-apiofuranosyl-（1″→6′）-β-D-glucopyranoside（8）， β-sitisterol（9）， daucosterol（10）， 3， 4-dihydroxy-benzaldehyde（11）， stigasterol（12）. Conclusion Chlorogenic acid， oleanolic acid， 3， 4-dihydroxy-benzaldehyde were the first cerebroside isolated from Sargentodoxa cuneata.