Objective To investigate the effects on level of sex hormone in perimenopausal syndrome patients treated with moxbustion at SP6 and RN4， and compare with the effects of moxa oil. Methods The patients were randomly divided into moxbustion group and moxa oil group. The patients of moxbustion group were treated with mild moxibustion at SP6 and RN4 while the patients of moxa oil group were treated with moxa oi smear at SP6 and RN4. Once every other day， a month for a course of treatment for the three course of treatment. The contents of FSH， LH and E2 were detected of two groups. Results After treatment， the contents of E2 patients of moxbustion group increased（P<0.01）， the contents of FSH and LH decreased（P<0.01）. The contents of FSH， LH and E2 were detected of moxa oil group have no significant change（P>0.05）. Conclusion Moxibustion at SP6 and RN4 could effective adjustment the level of sex hormone in perimenopausal syndrome patients.