Destroy in cell cycle regulation mechanism results in an out of control cell growth， which is a fundamentally common characteristic in almost all types of tumors. Active ingredients in several traditional Chinese medicines（TCM）can block cell cycle to inhibit cancer cell proliferation， generating an anti-tumor effect. Gastric cancer， as a common malignant tumors in digestive system with high death rate， has been the hotspot of tumor research. With the advance of technology， the mechanism of action for TCM against tumor is being gradually revealed. This article will review the effect and mechanism of TCM on gastric cancer cell cycle.