Objective This paper summarizes the latest literature， which can offer solid theoretical basis for Traditional Chinese Medicine treatment in diabetic wound. Methods This article summarizes the signaling pathways of Traditional Chinese medicine（TCM）regulate diabetic wound through refering to the literature in recent years. Results Clinical application and the result evaluation which using TCM treatment in treating Diabetic wound， show the unique advantages of multiple targets and multi-level of TCM regulate diabetic wound. Conclusion TCM regulate diabetic wound has its unique advantages， we can further explore its mechanisms.