Objective It is to approach the relationship between syndrome pattern of Chinese medicine and the levels of serum lipoprotein of frequent relase mesangial proliferative glomerulonephritis. Methods Detect the levels of serum lipoprotein、urine protein、urine NAG enzyme of frequent relase mesangial proliferative glomerulonephritis of child patient， analyse the relationship between the levels of serum lipoprotein、urine protein、urine NAG enzyme and syndrome pattern of Chinese medicine. Results The levels of TC of asdthenic splenonephro Yang group and hepatic and renal Yin deficiency group was higher than Gasthenia of pulmonosplenic Qi group（P<0.05）； the levels of TG of splenasthenic fluid-retention group was higher than Gasthenia of pulmonosplenic Qi group（P<0.05 ）； the levels of LDL-C of asdthenic splenonephro Yang group and hepatic and renal Yin deficiency group was higher than Gasthenia of pulmonosplenic Qi group （P<0.01）； the levels of apoAI of asdthenic splenonephro Yang group and was higher than Gasthenia of pulmonosplenic Qi group（P<0.01）； the levels of urine protein of asdthenic splenonephro Yang group and splenasthenic fluid-retention group was higher than Gasthenia of pulmonosplenic Qi group（P<0.01）； the levels of urine NAG enzyme of asdthenic splenonephro Yang group and splenasthenic fluid- retention group was higher than Gasthenia of pulmonosplenic Qi group（P<0.01）. Conclusion There was close relation between the change of serum lipoprotein and recurrence of children with frequent relase MsPGN， According to the Chinese medicine macro discriminate and renal needle biopsy， to analyzing the relationship between pathological changes of syndrome pattern of Chinese medicine and change of serum lipoprotein， could make for the intervention of traditional Chinese medicine for the diagnosis and treatment of the disease in time.