Objective To study the dogwood total terpene regulation of PCOS rats with insulin resistance and its mechanism of ovarian granular cells secrete. Methods Female SD rats subcutaneously age of 22， prasterone sulfate sodium 9 mg·100·d-1·g-1， a total of 20 days， 60 days with high fat diet feeding PCOS rats model with IR， PCOS rats were randomly divided into model group and treatment group. The treatment group with total terpene dogwood， chlorine meters Finn and rosiglitazone intervention. Glucose oxidase method determination of fasting blood glucose（FBG）. Ria method fasting insulin（Fins）， testosterone（T）， estradiol（E2）， promote the follicle-stimulating hormone（FSH） and luteinizing hormone（LH） content. At the same time， the random take each group two rats subcutaneously PMSG iu/kg， 10 cervical dislocation method executed after 48 h. Under aseptic conditions quickly profile control in the ovary， Pierce follicle， get ovarian granulosa cells. Observed ovarian morphology and granular cell distribution， chloride with dogwood total terpene and m intervention training， detection of granulosa cells to glucose intake and the amount of secretion and progesterone（P）. Results Compared with model way， the treatment group rats Fins concentrations were significantly lower（P<0.01）， ISI significantly increased（P<0.01）， T and E2 concentrations were significantly lower（P<0.01）， FSH concentration significantly increased（P<0.01）， layer number of particles in rat ovarian follicle cells increased significantly， progesterone secretion increased（P<0.05）， the ability of glucose uptake increased（P<0.05）. With chlorine meters compared with rosiglitazone double positive control group， no significant difference（P>0.05， P>0.05）. Conclusion Total terpene dogwood can improve insulin resistance， cell glucose uptake， and increase the production of estrogen and progesterone.