Objective To explore the clinical curative effect of ToutongXinNO. 1（TX1） in treating patients with chronic migraine headaches. Methods 80 cases of chronic migraine（CM） patients were randomly divided into two groups， evaluating the degree of anxiety and depression of patients with CM by Self-rating Anxiety Scale（SAS） and Self-rating Depression Scale（SDS）， the treatment group who received TX1； and the control group who received FlunarizineHydrochloride Capsules. The treatment lasted for 12 weeks. To observe the difference in two groups. Results There were significantly differences between two groups（P<0.001） in degree， frequency， and duration， before and after the therapy. The effective rates of clinical effect were 95% and 70% in treatment group and control group respectively， the difference was statistically significant（P<0.05）. After the therapy， the treatment group had the marked decrease in SAS and SDS（P<0.001）， and no marked difference in the control group（P>0.001）. Conclusion TX1 is Significantly effective in treating CM， and reducing the depression. CM should be treated based on wind， dampness， blood stasis， deficiency， and the depression.