Objective To evaluate the effective of Xiaoxianxiong Decoction combine with Sini-san for liver and stomach heat type of primary biliary reflux gastritis. Methods Simple random and control methods were used to random 132 patients to 4 groups：group of Xiaoxianxiong combine with Sini-san， Xiaoxianxiong group， Sini-san group and Domperidone group. These patients have been treated for 4 weeks， and followed-up for 4 weeks. Recording the changes of symptoms. Results During the treatment and followed-up， symptoms points of all groups decreased a lot （All P<0. 01）. Compare to Domperidone group， group of Xiaoxianxiong combine with Sini-san， Xiaoxianxiong group and Sini-san group can improve symptoms of stomach， bloating， belching， Acid reflux， disgusting， noisy， chest tightness， insomnia. Conclusion Xiaoxianxiong combine with Sini-san， Xiaoxianxiong Decoction， Sini-san can more effectively improve bile reflux gastritis patients’ symptoms than Domperidone.