Objective To observe the clinical curative effect of traditional Chinese medicine combined with chemotherapy in the treatment of advanced non-small cell lung cancer， the relative advantages of combination therapy in the treatment of advanced non-small cell lung cancer with integrated traditional Chinese and Western medicine. Methods In accordance with the standards of the 338 cases， in which the Chinese medicine combined with chemotherapy group of 161 cases， 177 cases of chemotherapy group. Comparison of two groups of curative effect in the near future， difference of clinical symptom score， KPS score， immune index， body weight and survival time. Results The traditional Chinese medicine combined with chemotherapy group and chemotherapy group efficiency is respectively 44.6%， 40.4%（P>0.05）， no statistically significant difference between the two groups. Traditional Chinese medicine combined with c. Traditional Chinese medicine combined with chemotherapy group was 81. 9%， higher than the overall stability of chemotherapy group and 66. 5%（P<0.05）， TCM combined with chemotherapy group in improving clinical symptoms， improve life quality， immune function and survival time were significantly better than the chemotherapy group（P<0.05）， stable body weight had no significant difference（P>0.05）. Conclusion Traditional Chinese medicine combined with chemotherapy group had no advantage in the stable weight， but it can improve in patients with advanced non-small cell lung cancer stability rate， and improve patient disease-related symptoms to a certain extent， improve the quality of life of patients， immune function and survival time.