Objective To observe the clinical effect on chronic renal failure（CRF）treated with Jianpiyishen Decotion and therapeutic apparatus for kidney diseases on specific acupoints. Methods Select 66 patients of stage 3-4 chronic kidney disease and treat them for 2 weeks. Divide the cases into two groups randomly， with 30 cases in control group and 36 cases in treatment group. The cases in control group were treated with Jianpiyishen Decotion， while the cases in treatment group were treated with Jianpiyishen Decotion and therapeutic apparatus for kidney diseases on specific acupoints. The clinical symptoms and changes of serum creatinine（Scr）and blood urea nitrogen（BUN）were observed. Results After the treatment， the symptoms of both groups lessened obviously much more than prior therapy（P＜0.01）. The symptom of treatment group was less severe than control group（P＜0.05）. The total effective rate was 86. 1% in treatment group and 70% in control group， but there was no different statistically. After the treatment， BUN and Scr levels of both groups decreased obviously（P＜0.01）， and Scr of treatment group decreased more obviously than control group（P＜0.01）. Conclusion The Jianpiyishen Decotion can treat CRF effectively and reduce Scr and BUN. Combination of Jianpiyishen Decotion and therapeutic apparatus for kidney diseases on specific acupoints can improve the curative effect.