When we diagnose and treatless weak sperm diseases， the influence of poison（radiation， high temperature， chemicals， heavy metals， etc. ） and worm （Sexually transmitted diseases， microbial infection） are becoming more and more obvious. This article discusses the development and treatment measures of the disease from three aspects， the formation， the pathogenesis and the therapies and aim to provide a new train of thought for the less weak sperm’s treatment， so as to improve clinical curative effect.