Objective To investigate protective effects of compound capsule of Pueraria lobata on liver injury induced by ethanol in Mice. Methods To investigate the compound capsule of Pueraria lobata（CCPL）（100，300，500mg/kg） on liver injury induced by 50% ethanol（12mL/kg. bw） in mice， and determine the active condition， serum alanine aminotransferase（ALT） and aspartate aminotransferase（AST） activities， liver malondialdehyde（MDA） content and glutathione peroxidase（GSH-Px） activity， and hepatic histopathologic changes. Results The results indicated that CCPL at the dose of 300 and 500mg/kg. bw could significantly decrease the serum ALT and AST activities， and significantly increase the hepatic GSH-Px activity of mice with liver injury induced by ethanol（P＜0.05 or P＜0.01）. Low， medium and high dose of CCPL could significantly reduce the liver MDA content on liver injury induced by ethanol in mice（P<0.05 or P<0.01）， and has concentration-response relationship， the biggest drop of 54.4%， and the high dose of CCPL has the same effect with positive control liver-protection tablet. In addition， CCPL could protect the hepatic histopathologic changes. Conclusion CCPL could significantly protect the liver injury induced by ethanol in mice， and this study laid a foundation for Pueraria lobata and CCPL exploitation to anti-alcohol and liver-protection dietary supplement or drug.