Objective To observe the effect of traditional Chinese medicine（TCM） combination therapy on functional dyspepsia with insomnia. Methods Compare to domperidone， the change of functional dyspepsia symptoms integral and Pittsburgh sleep quality index（PSQI） was investigated in 80 patients after 4 week’s treatment. Results Functional dyspepsia symptoms integral and PSQI were reduced by TCM combination therapy and domperidone（P<0.05）， but TCM combination therapy was better（P<0.05）. Conclusion TCM combination therapy is quite effective for functional dyspepsia with insomnia.