Treatise on exogenous febrile disease is the classical works by ZhangZhongjing. The thought of protecting spleen and stomach and middle-jiao have a huge impact on physicians of past generations. Through analying the treatment， medication and nursing methods of Guizhi decoction syndrome， Banxia Xiexin decoction syndrome， Ten jujube decoction syndrome， Bai Hu decoction syndrome， Xiaochaihu decoction syndrome， Chaihu Guizhi Ganjiang decoction， Xiaojianzhong decoction syndrome of Treatise on exogenous febrile disease， Zhang Zhongjing’s thought of protecting spleen and stomach is explored from five aspects：strengthening the spleen and stomach to harmonize yingfen and weifen， using of cold and warm simultaneously to strengthening the spleen and eliminating pathogenic effects， eliminating pathogenic effects and protecting spleen to protection of vital qi， nourishing the spleen during treating liver disease to strengthening vital qi and eliminating pathogenic effects， warming and invigorating spleen and stomach to regulating middle energizer and tonify deficiency.