Objective To observe the effect of middle-warming and spleen-strengthening and kidney-tonifying therapy on lowering glucose， regulating blood lipid， increasing insulin sensitivity and decreasing body mass index in type 2 diabetes mellitus patients. Methods 105 cases of patients with type 2 diabetes， according to the proportion of 2:1 were randomly divided into the Chinese medicine group of 70 cases and the control group (metformin group) 35 cases. The course of treatment lasted 8 weeks． Blood glucose， glycosylated hemoglobin， blood lipids， fasting insulin， insulin sensitivity index and body mass index were observed in the two groups before and after intervention. Results After treatment insulin sensitivity and high density lipoprotein cholesterol were improved in the Chinese medicine group（P＜0.05）. Blood glucose， glycosylated hemoglobin， triglycerides， high fasting insulin and body mass index decreased in the Chinese medicine group（P＜0.05）. Compared with the control group， the effect on lowering the fasting blood glucose， 2-hour postprandial glucose and glycosylated hemoglobin were equivalent（P＞0.05）. While the effect on lowering triglycerides， high fasting insulin and body mass index as well as improving the efficacy of insulin sensitivity and high density lipoprotein cholesterol， the Chinese medicine group is better than the control group（P＜0.05）. Conclusion Middle-warming and spleen-strengthening and kidney-tonifying therapy exerts better curative effect for T2DM patients.