Objective To discuss the effect of revision with Danggui shaoyao powder combined Guizhi fuling pill to TCM syndromes of simple ovarian cyst and ovarian cyst volume， and to judge the comprehensive therapeutic effect. Methods 120 cases suffering from simple ovarian cyst were selected， and they were Divided into danggui shaoyao powder Group， guizhi fuling pill group and revision with Danggui shaoyao powder combined Guizhi fuling pill group at random. All cases were admitted treatment for 3 menstrual cycles and evaluated TCM syndromes and cyst volume before and after treatment. The comprehensive therapeutic effect was evaluated after treatment. Results After trestment， TCM syndromes and ovarian cyst volume of three groups were all decreased compared with before treatment（P<0.01）. The descent of TCM syndromes， ovarian cyst volume and the comprehensive therapeutic effect of revision with danggui shaoyao powder combined guizhi fuling pill group was better than danggui shaoyao powder group and guizhi fuling pill group（P<0.05）. There were no statistically significant differences between danggui shaoyao powder group and guizhi fuling pill group of TCM syndromes， ovarian cyst volume and the comprehensive therapeutic effect（P>0.05）. Conclusion Revision with danggui shaoyao powder combined guizhi fuling pill was an effective drug to ameliorating TCM syndromes and ovarian cyst volume of simple ovarian cyst， and its comprehensive therapeutic effect was better than danggui shaoyao powder and guizhi fuling pill.