Objective The purpose of this article is to through the animal experiment， study the effect of Yiqi-huoxue medicine on the emotional stress of myocardial ischemia model rats， adponectin contant in heart and brain， to provide a theoretical ideas and basis for Yiqi-huoxue medicine in prevention and treatment of cardiovascular diseases. Methods Adopt the method of intraperitoneal injection of epinephrine（5 mg/kg·d）， and chronic unpredictability emotional stimuli to make complexsrats under emotional stress state. Animals are divided into five group： Blank group， ISO model group， Complex model group， Chinese medicine group， Western medicine groups. Using ultrasonic electrocardiogram， monitoring method to record the heart function， using the RT-PCR method for determinate the level of adponectin in heart and brain. According to these indexes of every group in the experimental process， respectively to observe contrast the changes of different groups after 14 and 28 days， treatment. Results After 32 days， the ejection fraction（EF） of complex model group， and fractional shortening（FS） were lower than those of blank group， the difference was statistically significant（P<0.01）； adponectin contents in complex model group and ISO model group were higher than that in blank group， the difference was statistically significant（P<0.01 or P<0.05）； adponectin contents in traditional Chinese medicine group and Western medicine group were lower than the complex model group， the difference was statistically significant （P<0.01 or P<0.05）. Conclusion The reason why Yiqi-huoxue medicine can increase cardiac ejection fraction of rats in complex model group may be according to its effect on adponectin.