Objective To evaluate the clinical effectiveness of fire needle combined with Halometasone in the treatment of prurigo nodularis. Methods 120 patients of prurito nodularis with typical clinical appearance were divided into three groups randomly. The treatment group was given fire needle and Halometasone. Two controls groups were given fire needle and Halometasone respectively. The duration of treatment was four weeks. Results After four weeks’ treatment， the effective rates for treatment group and fire needle were 95.00% and 80.00%， and the difference was statistically significant（P<0.05）. The difference of effective rates between treatment group and Halometasone group（72.5%） was also statistically significant（P<0.05）. Conclusions Fire needle combined with Halometasone in the treatment of prurito nodularis can significantly improve the effectiveness.