Objective To investigate the effect of acupuncture point injection astragalus injection combined with trimebutine on diarrhea-predominant irritable bowel syndrome（IBS-D）. Methods Using the randomized controlled method， ninety-six IBS-D were divided into a treatment group（47 cases） and control group（49 cases）. Both groups received trimebutine， one tablet each time， three times a day， taking two weeks， the treatment group received point Xinshu， Ganshu， Pishu injection of astragalus in addition， a total of seven times in treatment. After two weeks， using the IBS-SSS scale for patients at the end of the treatment， one month and three months to evaluate clinical synmptoms improve the situation. Results IBS-SSS score was improved significantly after treatment in the two groups（P<0.05）， and the improvements in the treatment group were superior to those in control group after treatment and 1 month（P<0.05）， however， 3 month after treatment in the two groups there was no statiscally significant difference（P>0.05）. In terms of clinical symptoms improved， the treatment group improved in terms of frequency of abdominal pain and abdominal pain was better than control group， the difference was statistically significant（P<0.05）. Conclusion The method of acupuncture point injection astragalus injection combined with trimebutine can alleviate the symptoms of IBS-D and it is effective.