Objective To investigate the effect of Shenqi Qiangxin Capsule on Heart Function and Serum N-terminal Pro-Brain Natriuretic Peptide Tumor Necrosis Factor-α in patients with chronic heart failure. Methods 80 patients were divided into the randomly treatment group and the control group. Both groups were treated with regular treatment for 4 weeks. Simultaneously the Shenqiqiangxin capsule was added into the treatment group. We observe the changes of Clinical Efficacy、LVESV、LVEDV、LVEF、NT-proBNP and TNF-α in 80 cases before and after therapy. Results Clinical Efficacy、LVESV、LVEDV、LVEF、NT-proBNP and TNF-α were promoted after therapy in the two groups， the deference of reatment group was obvious than control group. Conclusion Shenqi Qiangxin capsule can improve the levels of LVESV、LVEDV、NT-proBNP and TNF-α in patients with chronic heart failure and improve clinical efficacy， inceased LVEF， improvement of left ventricular function.