Objective Observation of the clinical therapeutic effect of Yifei Xuanfei Jiangzhuo Capsule on mild-to-moderate vascular dementia to explore its the degree of reaction of chemotherapy. Methods Eighty patients with mild-to-moderate vascular dementia were randomly divided into treatment group and control group with randomized-double blind and controlled design method， each group for 40 cases， respectively. The treatment group was accepted Yifei Xuanfei Jiangzhuo Capsule， while the control group was accepted Piracetam by oral. The changes such as the curative effect of TCM syndrome， The syndroms integral of TCM symptom（SDSVD）， Loewenstein Occupational Therapy Cognitive Assessment（LOTCA）， The daily living ability（ADL）， and The safety of the drug were observed. Results The curative effect of TCM syndrome， SDSVD、 LOTCA， and ADL in 2 groups above were both signi cantly higher than those before treatment（P<0.05）， with the treatment group being more obvious than the control group（P<0.05）. Conclusion Yifei Xuanfei Jiangzhuo Capsule could effectively improve the SDSVD、 LOTCA， and the curative effect of TCM syndrome on patients with mild-to-moderate vascular dementia， It obtains definite curative effect， and deserves to be spread and is studied further in the clinic.