Objective To observe the effect of Painengda on peripheral blood cell count and symptoms of patients with Chronic Hepatitis B and Liver fibrosis， explore whether can it strengthen the curative effect of nucleoside analogues， and help in treatment of Chronic Hepatitis B and Liver fibrosis. Methods The selected 60 patients were randomly assigned to two Groups（30 patients in each group）， the control group were treated by nucleoside analogues（Lamivudine 100mg and Adefovir 10mg once a day）while the treated group were treated by nucleoside analogues（the same as the control group） and Painengda， which dose was 2 pills twice a day. After 6 months， the treatment of Painengda was stopped， the treatment of nucleoside analogues going on in both of the groups. Then compared syndrome integral of two groups and compared the peripheral blood cell count of patients with low level of WBC（<4×109/L） and（or） PLT（<100×109/L）. Results 1. The WBC level in the treated group was obviously enhanced than in the control group（P<0.05）； 2. The PLT level raised in each group after therapy， but there were no statistical differences in each group itself or between the two groups； 3. The syndrome integral decreased in both of the two groups after treatment（P<0.05）， while the treated group’s lower（P<0.05）. Conclusion Painengda can improve the curative effect of nucleoside analogues， increase the count of WBC and PLT and improve the clinical symptoms， creating a better quality of life.