Objective To analyze the effect of acupoint injection of metoclopramide into Tsusanli as a way to prevent nausea and vomiting during chemotherapy of malignant tumor. Methods Through retrieval of clinical literature about the effect of acupoint injection of metoclopramide in preventing nausea and vomiting caused by chemotherapy of malignant tumor， which includes Wanfang Database， CNKI， Chongqing Weipu Database， PubMed， CBM， and incorporated with randomized controlled trials and clinical controlled trials in the case of prevention of nausea and vomiting caused by chemotherapy and by the means of making comparison between Treatment group where acupoint injection of metoclopramide was combined with the use of 5-HT3 receptor antagonist and Control group where only 5-HT3 receptor antagonist was used. Afterwards. the analysis of quality was carried out and effective data were extracted. which underwent Meta analysis using RevMan5.2 software. Results Incorporated with 5 literature， and 254 patients. Meta analysis indicated that in the case of prevention of nausea and vomiting caused by chemotherapy， the difference in total efficiency between acupoint injection of metoclopramide with combination of 5-HT3 receptor antagonist and sole use of 5-HT3 receptor antagonist was of statistical significance[polled random effects model（RR）=6.59， 95% confidence interval （3.53， 12.28）， Z=5.93， P<0.01]. Conclusion In the case of prevention of nausea and vomiting caused by chemotherapy， the total efficiency of acupoint injection of metoclopramide with combination of 5-HT3 receptor antagonist was superior to that of the sole use of 5-HT3 receptor antagonist. Therefore， the preliminary conclusion suggests that the method of acupoint injection of metoclopramide with combination of 5-HT3 receptor antagonist is effective in preventing nausea and vomiting caused by chemotherapy.