Objective To observe the effect of Painengda on the negative rate of HBeAg and IL-2 level of patients with Chronic Hepatitis B and Liver fibrosis， investigate whether it can improve the curative effect of anti hepatitis B virus， and supply help in treatment of patients with Chronic Hepatitis B and Liver fibrosis. Methods The selected 60 patients were randomly assigned to twoGroups（30 patients in each group）， the control group were treated by nucleoside analogues（Lamivudine 100mg and Adefovir 10mg once a day） while the treated group were treated by nucleoside analogues（the same as the control group） and Painengda， which dose was 2 pills twice a day. After 6 months， the treatment of Painengda was stopped， the treatment of nucleoside analogues going on in both of the groups and followed up for 9 months. In the study， every 3 months the detection of hepatitis B three was done； IL-2 levels were detected before and after treatmet. Results In the sixth and ninth month after the treatment of Painengda， the negative rate of HBeAg in the treated group was higher than that in the control group（P<0. 05）； The IL-2 level was higher in the treated group than that in the control group， too（P<0. 05）；In the treated group itself ， IL-2 level was enhanced after treatment （P<0. 05）. Conclusion Painengda combined with western medicine can improve the negative rate of HBeAg and improve the curative effect of anti hepatitis B virus， which helps more in treatment of patients with Chronic Hepatitis B and Liver fibrosis.