Objective To observe the clinical effect of oral ShenWei gubi decoction in the treatment of liver and kidney deficiency， cold ampness osteoarthritis. Methods According to the diagnosis and the inclusion criteria for this disease were 190 cases were randomly divided into treatment group 103 cases and control group 87 cases， control group using diclofenac sodium sustained release capsules（Ying Taiqing） orally， treatment group was treated with Shen WeiGubi decoction， Were observed before and after treatment Lequesne index score and TCM syndrome integral and curative effect evaluation. Results Two groups after treament and efficient treatment group was obviously higher than that of cintrol group， the difference was statistically significant（P<0.05）. Conclusion Oral Shen WeiGubi decoction Treated effective in clinical practice.