Objective To observe the effect of Jianpi Yishen Decoction on hemodialysis patients with secondary hyperparathyroidism. Methods 60 patients of them were randomly divided into two groups，“treatment group of 30 cases” and “control group of 30 cases”. The treatment group was used with Jianpi Yishen Decoction oral Combined with basic hemodialysis （Twice hemodialysis and once hemodiafiltration every week， using drugs including erythropoietin， dialysis parameters such as blood flow， dialyzer and dialysis machine models were the same）. The control group of 30 cases was cured with basic hemodialysis. Its index of bone pain degree，itching degree，PTH、 Ca、 P、 K+、 FGF-23、 Leptin and 1，25（OH）2D3 were compared. Results The bone pain degree and skin itching， including BUN、 Scr、 Leptin of treatment group compared with the control group were significant differences（P<0.05 or P<0.01）； but the PTH， Ca， P， K+， FGF-23，1，25（OH）2D3 testings of treatment group compared with the control group， had no significant difference（P>0.05）. Conclusion Jianpi Yishen Decoction Combined with basic hemodialysis treatment can obviously relieve bone pain and skin itching degree， reduce the BUN、 Scr、 Leptin values， Without affecting the blood of K+， and Can reduce PTH， Ca， P， FGF-23，1，25（OH）2D3 values， even if without statistical significance.