Objective Reduning injection（Reduning injection， RI） to treat children with pneumonia， but the specific treatment for children with community-acquired pneumonia（Community-acquired pneumonia， CAP） remains unclear. Methods This study used a randomized， double-blind， placebo-controlled Reduning Injection clinical trials， patients treated with antibiotics after hospital auxiliary imaging confirmed community-acquired pneumonia（age 12-36 months）. Trial group using 5 mL of normal saline RI adding 100 mL intravenous infusion once daily for 7 days. Using 100 mL of normal saline placebo intravenously add 5 mL of normal saline for intravenous infusion. Drip rate of 10-15 drops per min， once per day. Results The study included 1198 cases of children. RI during hospitalization can significantly shorten the overall length of hospital stay in children（P<0.001）. In addition， Reduning group can significantly reduce the incidence of severe sepsis hospitalization（P=0.02）， while it able to improve the clinical symptoms， significantly reduced breathlessness（P=0.001） and reduced the duration of fever（P=0.000）. Conclusion This randomized clinical trial for the treatment of CAP application RI children to provide evidence of the positive evidence supporting the beneficial of Reduning Injection for children with acute pneumonia.