CHEN Xiuyuan is a famous doctor in Qing Dynasty， who rather esteemed classical works of TCM and Paid more attention to the effect of clinical practice. He believed that the knowledge of the cause and the pathogenesis of the apoplexy focused on exopathic wind and put forward the theory of the six meridians syndrome differentiation from meridian， blood vessels， Zang-Organ and Fu-Organ， respectively. Which based on the transmission law of pathogenic wind andthe system of the six meridians syndrome differentiation. CHEN Xiuyuan applied the theory and rule in treating stroke which fit with classical works of TCM andalso be effect in clinical practice.