Animal models of neuropathic pain provide pivotal system for preclinical study， for the similarity to clinical neuropathic pain syndromes.However， the complex and various pathogenesis of neuropathic pain call for differential and relevant animal models of neuropathic pain. This article reviews four of the most widely used and promising new models of neuropathic pain. Chronic constriction injury model（CCI）， partial spinal ligation model（PSL）， and spinal nerve ligation model（SNL） represent three of the best characterized rodent models of peripheral neuropathy. While， spared nerve injury model（SNI） have been widely and recently reported. All of them are established to study the molecular mechanism of pain， especially for neurotransmitter release and signal transduction. Each model is uniquely created with distinct mechanisms， it is therefore essential to report and interpret results in the context.