Objective This paper servers as a literrature review of previous study on molecular Biological mechanism accounting for obstinate diabetic foot ulcer which is hard to heal， laying substantial theoretical foundation for further effective promotion for curing diabetic foot ulcer and reduction of related amputation cases. Methods Data collection of pertinent reference and documents from CNKI and PubMed database. Results Analysis for the mechanism via which diabetic foot ulcer is difficult to be defeated from the perspective of molecular biology. Conclusion The mechanism accounting for obstinate diabetic foot ulcer disease is a complex one involving considerable factors which is still in great demand to be studied further， For future research， it’s a necessity yet a must to provide more evidence to verify and support existed therapy theories by plenty of clinical cases study.