Objective Investigate the effect of rat spleen stomach damp heat syndrome lesions from Wang’s lianpu drink effect on epithelial cells of the gastric mucosa p53， bcl-2 protein. Methods Sixty SD rats were randomly divided into normal group， normal saline group， omeprazole group， Wang’s lianpu drink high， medium and low dose group 6 groups with 10 rats in each group. In addition to the normal group， the rats by intraperitoneal injection of the dosage of the 10 mL/kg， salmonella typhi，according to 5 mL/kg again after 24 hours to fill the stomach， combined with high fat and sugar diet and environment were induced copy taste hot and humid card model， such as composite factor determined by hot and humid card lesions， gastric mucosa pathological materials adopt normal chemical method to detect and analyze the rat gastric mucosa of the Bcl -2 P53 protein target. Results Omeprazole group，wang’s Lianpu drink high，medium and low dose group and model group the Bcl-2，P53 protein expression significantly increased in the normal group（P<0.05）. After treatment， compared with normal saline group，omeprazole group， wang’s Lianpu drink（high， medium and low dose group of the Bcl-2， P53 protein expression incremental reduction， but wang’s Lianpu drink between low dose group and omeprazole group there was no significant difference（P>0.05）， wang’s Lianpu drink high dose group is better than that of middle and low dose group and omeprazole group， difference was statistically significant（P<0.05）. Conclusion Wang’s Lianpu drink can improve the spleen and stomach damp heat syndrome of gastric mucosal epithelial lesions， its mechanism may be related to the regulation of p53 and Bcl-2 proteins.