Objective To investigate the clinical efficacy of abdominal acupuncture combining with anti-depressant in treating fibromyalgia syndrome. Methods Fifty patients with fibromyalgia syndrome were randomly allocated to treatment group and control group. The treatment group received abdominal acupuncture combining with anti-depressant and the control group with anti-depressant. The therapeutic effects were evaluated using a scale. Results Pain， sleep， depression and other symptoms all improved more in the group of fibromyalgia syndrome patients than in the control group after 3 and 6 weeks of treatment（P<0.05）. Conclusions Abdominal acupuncture combined with anti-depressant is an effective way to treat the fibromyalgia syndrome.