Objective To observe the clinical efficacy of Shugan Lidan Granules Composed of Twelve Traditional Chinese Medicine combined with endoscopic retrograde cholangio-pancreatography（ERCP） in treatment of common bile duct stones. Methods A randomized controlled trial was performed in patients with common bile duct stones， who were divided into study group（n=30） and control group（n=30）. The control group underwent ERCP followed by Inhibition enzymes and anti-infective therapy， while the study group was orally given Shugan Lidan Granules composed of twelve traditional Chinese medicines in addition to the treatment for the control group. After treatment， the clinical outcomes， routine blood indices（leukocytes， neutrophils， and Percentage of neutrophils）， liver function indices（aspartate aminotransferase， alanine aminotransferase， alkaline phosphatase， and glutamyl transpeptidase）， Serum amylase， serum bile acid and bilirubin levels（total bile acid， total bilirubin， direct bilirubin， and indirect bilirubin）， and Nasal duct-tube drainage volume were evaluated. Results Compared with before treatment， there was significantly difference in clinical symptom， routine blood indices， liver function indices， and Serum amylase， serum bile acid and bilirubin levels（P<0.05）； and significantly larger bile drainage volume compared with the control group（P<0.05）. Conclusion ERCP combined with oral administration of Shugan Lidan Granules are helpful for controlling postoperative bile duct inflammation， promoting postoperative recovery of liver function， reducing postoperative amylase and removal of residual stones， and preventing stone recurrence.