Objective To observe the curative effect of peitu wenshui formula on slow transit constipation（STC）. Methods The STC patient（n=120） were divided into the treatment group（treated with peitu and wenshui formula， n=60） and control group（treated with Mosapride Citrate Tablets， n=60）. To observe the relief of STC after 4 weeks. Results The total effective rate was 91.78% in the treatment group and 61.67% in the control group， The normal rate of stool property was 86. 67% and 56.67% in the control group. The comparison between two groups was significantly different（P<0.05）. Conclusion The treatment with Peitu Wenshui formula has more significant curative effect.