Objective To observe the clinical effect of local injections with glucocorticoid for alopecia areata（AA） patients who with eyebrow loss. Methods 60 AA patients with eyebrow loss were divided into three groups in order of been diagnosed initially. 20 cases in the treatment group were treated with diprospan suspension localized injection biweekly and hair-promoting capsulesⅠorally taken five capsules per time and three times per day； 20 cases in the control groupⅠwere treated with diprospan suspension localized injection biweekly； 20 cases in the control groupⅡwere treated with hair-promoting capsulesⅠorally taken five capsules per time and three times per day； The injection of the glucocorticoid suspension was stopped after 8 weeks， while hair-promoting capsuleⅠwas continued to 12 weekends. The observational indicator was evaluated at baseline， 2nd weekends， 4th weekends， 8th weekends and 12th weekends after treatment. Results The difference of clinical effects showed significance as time goes on（F=218. 253， P<0.01）； Time factors and group factors had interactive effects on clinical effects： the clinical effect of treatment group and control group showed gradual improvement as time goes on（F=7. 709， P<0.01）； The clinical effect of treatment groups were more significant than control group（P<0.01）， the difference between control groupⅠand control groupⅡ was not obvious（P>0.05）. Conclusion The glucocorticoid localized injection has many characteristics with simplicity operation， quickly and precisely clinic effect， and its side effect would gradually resolved as time goes on after glucocorticoid withdrawl. Combination of glucocorticoid localized injection and hair-promoting capsulesⅠorally taken is worth to promote to treat AA patients with eyebrow loss symptom.