Objective To investigate the effect of Jianpi decoctions--ShenLingBaiZhu powder and LiuJunZiTang on skin barrier by using a mice skin barrier dysfunction model． Methods The mouse model of skin barrier dysfunction was made by repeated tape stripping. The Transepidermal Water Loss（TEWL）， epidermis thickness and content of epidermal ceramides were tested among normal group， model group and Jianpi decoction groups. Results The TEWL and epidermis thickness of models were increased and content of epidermal ceramides was decreased than normal group. The TEWL and epidermis thickness in each group of Jianpi decoction groups were significantly lower than that of model group. Content of epidermal ceramides in Jianpi decoction groups were higher than model group. Conclusion Jianpi decoctions could improve the function of skin mechanical barrier， the mechanism of which was related to increase of the content of epidermal ceramides. The effects of strengthening the spleen and removing dampness was better than strengthening the spleen and replenishing qi.