Objective To study effect of Qingre Jiedu Huazhuo tablets on IL-8 and IL-10 in rat model of liver and lung injuries induced by intestinal endotoxemia（IETM）. Methods The rat liver model was established by feeding them high sugar， fat and liquor. The rats were randomly divided into 3 groups. Qingre Jiedu Huazhuo tablets were used to treat liver inflammatory model rat for 4 weeks. The content of blood serum alanine transaminase（ALT）， aspartate transaminase（AST）， gamma glutamyltransferase（GGT）， alkaline phosphatase（ALP） were measured by colorimetry， lipopolysaccharides（LPS） was measured by tachypleus amebocyte lysate（TAL）， Pathologic change of liver was measured by a microscope， the two-step method of immunohistochemistry（IH） was adopted to test portein expression of liver and lung tissues interleukin-8（IL-8）， interleukin-10（IL-10）. Results Light microscopic inspection：the Qingre Jiedu Huazhuo tablets can suppress liver and lung inflammation. The expression of serum ALT， AST， GGT， ALP in model group were markedly higher than those in normal control group（P<0.01， P<0.05）. The expression of plasma LPS was markedly higher too（P<0.01）； The expression of IL-8 in liver and lung were markedly higher than those in normal control group（P<0.01）. Compared with model group， the serum expression of ALT， AST， GGT， ALP were significantly lower in Qingre Jiedu Huazhuo tablets group（P<0.01， P<0.05）. The expression of plasma LPS was markedly lower too（P<0.01）. Qingre Jiedu Huazhuo tablets can significantly reduce the gray sale of IL-8（P<0.01）and increase the gray sale of IL-10（P<0.01）. Conclusions Qingre Jiedu Hua zhuo tablets can resist inflammatory injury， which mechanism may be associated with reduced promoting inflammatory cytokines IL-8and LPS， release the anti-inflammatory cytokine IL-10 expression.