Objective To optimize the extraction process of puerarin in Babu agent for neck pain of extract. Methods The extraction amount of puerarin and the yield of extract were selected as the CCD-RSM was conducted to predict the optimal extraction process. Results The optimal conditions of extraction process were determined as follows：adding 8.7 times of water， refluxing 3 times， 1.85h for each time. Conclusion Under the optimal conditions， the extraction rate of puerarin was higher， the yield of extract is higher， the optimized extraction technology was stable， feasible and suitable for pilot scale test.