Objective To establish the fingerprint of Xuesaitong dispersible tablets， and control the quality stability of products by the similarity value stability. Methods Gradient elution by reversed phase high performance liquid chromatography， agilent chromatography column. The mobile phase was acetonitrile and water gradient elution， flow rate of 1ml/min， UV detection wavelength at 203nm， column temperature at（25±0.5）℃， the sample size of 20μL， and the chromatographic fingerprint evaluation system software was evaluated. Results To take the control of Panax notoginseng saponins as a veference， Panax notoginseng saponin R1， ginseng saponin Rg1， Re， Rb1， Rd were common peaks， and the fingerprint evaluation system was established of Xuesaitong dispersible tablets， the quality was evaluated by the fingerprint chromatogram similarity value and relative retention time etc. parameters of different batches of Xuesaitong injection points scattered pieces of the HPLC fingerprints. Conclusion The fingerprint established by this method has good reproducibility and precision， which applies to the quality control of Xuesaitong dispersed tablet’s.